FlexiOss® Dent
Modern implantable biomaterial for dental and maxillofacial procedures. Available in 1cm, 3cm, and 5cm sizes.
Third-generation biphasic (hydroxyapatite-polymeric) biomaterial, bioactive, supporting bone tissue regeneration. After implantation, it integrates with the patient's bone and is slowly remodelled into natural bone tissue — eliminating the need for reoperation.
Product Demonstrations
FlexiOss® Dent — Easy & Effective Bone Matrix
Product overview showcasing the dental bone filler properties, flexibility, and clinical applications.
FlexiOss® — Clinical Application
Clinical demonstration of FlexiOss® in dental procedures including socket preservation and bone augmentation.
What Makes FlexiOss® Dent Unique
Flexible After Soaking
Plastic and bendable — fits individual bone defects by cutting or bending
Bio-Compatible
Compatible with natural bone tissue for seamless integration
Mechanical Parameters
Similar to those of cancellous bone — structural support
Supports Bone Reconstruction
Actively supports the bone reconstruction process
Absorbs Blood & Medicine
High soaking capacity for enhanced drug delivery
Bone Tissue Regeneration
Positively affects bone tissue regeneration process
Ionic Reactive / Bioactive
High ionic reactivity increases mineralization rate
Non-Toxic Material
Thoroughly tested for safety — no cytotoxicity
Up to 7cm Defects
Can be used for bone defects of up to 7 cm in length
Non-Animal Material
Lowers risk of pathogen transmission and allergic reactions
Easy to Store & Transport
Simple storage and transportation requirements
Surgical Advantages
Surgical Handiness
Allows fitting during operation to the shape of individual bone defects by cutting or bending.
Can Be Milled
In dry state, FlexiOss® Dent can be milled for personalized composite implants.
Faster Ossification
High specific surface area and ionic reactivity increases mineralization rate and new bone formation.
Minimizes Contamination Risk
Curdlan polymer minimizes virus/prion risk. Forms collagen-like triple helix neutral to macrophages.
High Soaking Capacity
Can be soaked in antibacterial drugs, PRP, or growth factors, resembling expensive BMP-2-type substitutes.
Barrier Function
Helps prevent the migration of soft-tissue cells into the bone defect. Used standalone or combined with other grafting materials.
Easy Storage & Transport
No special conditions needed. Simple logistics for clinics worldwide.
Maxillofacial Applications
FlexiOss® Dent vs BonAlive®
A side-by-side against S53P4 bioactive glass granules for cranio-maxillofacial reconstruction. Every figure is drawn from each manufacturer's own published documentation.
| Attribute | FlexiOss® Dent | BonAlive® Granules / CMF |
|---|---|---|
| Product form | Pre-formed sterile cylinder in a double paper-foil pack, ready to place | Bioactive glass granules in an individually packaged, pre-filled syringe |
| Available sizes | Ø13 mm cylinder in 1 cm, 3 cm and 5 cm lengths | Granules: 1cc, 2.5cc, 5cc, 10cc. CMF: 2.5cc, 5cc |
| Composition | HAP granules (>100 nm) bound with curdlan, a β-1,3 glucan sugar polymer | S53P4 bioactive glass: 53% SiO₂, 23% Na₂O, 20% CaO, 4% P₂O₅ |
| Porosity | Micro and macroporous, ~30 µm pores, 68 to 70% porosity | Solid granules. Porosity is limited to the inter-granular space plus a surface hydroxyapatite layer |
| Handling & absorption | Absorbs blood and plasma, becoming malleable and trimmable during surgery | Does not absorb fluids. Moistened with saline before implantation. Volume and weight stay unchanged |
| Intraoperative preparation | Ready out of pack, no lengthy preparation | Requires saline injection into the granule syringe and spatula assembly |
| Intraoperative safety | No loose granules to migrate, no glove-puncture risk | Displaced granules can abrade nearby articular surfaces. Granules can puncture surgical gloves, a contamination risk |
| Osteoconductivity | Osteoconductive scaffold with strong osseointegration, supports vascularisation | Osteoconductive and osteostimulating (non-osteoinductive) |
| Resorbability | HAP resorbs. Curdlan degrades to glucose that enters normal metabolism | Forms a silica gel layer that crystallises to resorbable hydroxyapatite, replacing bone over several years |
| Animal or human tissue | None | None |
| Immunological / toxic reaction | None | Contraindicated in patients allergic to bioactive glass |
| Sterilisation | Ethylene oxide | Irradiation |
| X-ray visibility | Yes | Yes, also visible on CT and MRI |
| Indications | Small and large cavities across orthopedics, traumatology, dental and veterinary surgery | Cranio-maxillofacial (mandible, frontal-sinus and mastoid obliteration, nasal-cavity narrowing). Also orthopedic cavity and osteomyelitis filling |
Comparison drawn from Medical Inventi S.A. and Bonalive Biomaterials Ltd. manufacturer documentation (BonAlive® Granules and Granules CMF Instructions For Use). Provided for clinical reference.
No lengthy preparation
FlexiOss® is ready to place straight from the pack. BonAlive® requires saline to be injected into the granule syringe and a spatula assembled before use.
No granule migration
FlexiOss® stays where it is placed. Loose BonAlive® granules can travel beyond the implanted area and abrade nearby articular surfaces, impeding movement.
No glove-puncture risk
The cohesive FlexiOss® cylinder carries no puncture hazard. BonAlive® granules can perforate surgical gloves, introducing a microbiological contamination risk.
Delivered EO-sterile
FlexiOss® is sterilised with ethylene oxide and supplied to the customer ready for the operating field.
PhilHealth Subsidy & Co-Payment Guide
Understand your PhilHealth subsidy allowance and co-payment options for procedures that use FlexiOss® — written for both patients and clinicians.
Biphasic Formula
Biphasic (hydroxyapatite-polymeric) composite obtained by polymer gelling into an irreversible, collagen-like triple helix — neutral for macrophages, no local inflammation.
Hydroxyapatite (HAP)
Ceramic Phase
Low-sintered, highly porous ceramic
Fully synthetic — high chemical stability
Active bone regeneration via ion uptake
Curdlan Polymer
Polymeric Phase
Triple-helix (collagen-like) structure
Non-inflammatory conformation
Enables flexibility & high absorbency
Clinical Uses
Post-extraction alveolar bone augmentation
Dental implant site preparation and preservation
Maxillofacial reconstructive procedures
Treatment of gingival resection with bone atrophy
Filling defects after cystotomy and root resection
Oronasal fistulae treatment and closure
Open socket preservation without membrane
Bioactive filling of titanium scaffolds in implantology
Treatment of dental cysts
Interdental bone tissue regeneration
Mastoid cavity obliteration following cholesteatoma surgery (tympanomastoidectomy)
Temporal-bone / skull-base defect filling after cerebellopontine angle (CPA) tumor excision
Available Sizes
Certifications & Patents
CE Certified
EC No. 1434-MDD-269/2021
European conformity — highest safety standards
PH-FDA Approved
CMDR-2025-04943B
Certified for dental & maxillofacial applications in the Philippines
Patent Protected
European Patents
Protected across England, Austria, France, Spain, Ireland, Germany, Poland & Italy
International Recognition
The FlexiOss® technology and its inventors have been recognised by leading scientific and intellectual-property institutions.
Best Invention by a Woman Inventor
World Intellectual Property Organization (WIPO / OMPI)
Prix Galien Poland, Innovative Scientific Discovery
Prix Galien Foundation
Economic Award of the President of Poland, Research & Development
Office of the President of the Republic of Poland
Future Product of the Entrepreneur
21st Polish Future Product Competition
Developed and manufactured by Medical Inventi S.A. (Poland). Exclusively distributed in the Philippines by Fortschritt Medical Supplies Inc.
Documented Results
Oronasal Fistula Treatment
Cat oronasal fistula filling procedure with X-ray evaluation directly after implantation and 1 month post-op showing positive integration.
Canine Oronasal Fistula
Dog oronasal fistula filling — removal of luxated canine tooth and filling of the fistula with FlexiOss® Dent biomaterial.
Bone Density Progression
MicroCT (pQCT) evaluation showing bone density increase from implantation through 1, 3, and 6 months — confirming progressive bone formation.
Histological Integration
Histological images confirming bone cells, laminae, collagen fibres and Haversian canals at implantation site — unequivocal bone tissue formation.
Gingival Resection Treatment
Treatment of gingival resection with serious atrophy of interdental gingiva and bone tissue between 21st and 22nd teeth — successful regeneration.
Post-Cystotomy Filling
Successful filling of dental defect after cystotomy procedure — demonstrating remodelling and formation of bone tissue with no side effects.
Clinical observations conducted at New-Dent Stomatological Center, Lublin, Poland and Animal Surgery Clinic, University of Life Sciences, Lublin
Published Research
Efficacy of a Novel Adaptable and Moldable Synthetic Polymer, in Open Socket Preservation Without a Membrane: Ease of Use and Volume Preservation in Alveolar Bone RegenerationNEW 2026
Krasny K., Wróblewski S., Wojtowicz A., Kamiński A.
Engineering of Biomaterials (Inżynieria Biomateriałów) 174, 2026 · 2026
Behavior of new hydroxyapatite/glucan composite in human serum
Borkowski L., Lubek T., Jojczuk M., Nogalski A., Belcarz A., Palka K., Hajnos M., Ginalska G.
J. Biomed. Mater. Res. Part B, 2018 · 2018
Unexpected reaction of new HAp/glucan composite to environmental acidification: Defect or advantage?
Borkowski L., Kiernicka M., Belcarz A., Palka K., Hajnos M., Ginalska G.
Biomed. Mater. Res. B Appl. Biomater. 2017 · 2017
The comparison study of bioactivity between composites containing synthetic non-substituted and carbonate-substituted hydroxyapatite
Borkowski L., Sroka-Bartnicka A., et al.
Mater. Sci. Eng. C 2016, 62, 260-267 · 2016
Biphasic mode of antibacterial action of aminoglycoside antibiotics-loaded elastic hydroxyapatite-glucan composite
Belcarz A., Zima A., Ginalska G.
Int. J. Pharm. 2013, 454, 285-295 · 2013
Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair
Belcarz A., Ginalska G., Pycka T., et al.
Centr. Eur. J. Biol. 2013, 8, 534-548 · 2013
Efficacy of a Novel Adaptable and Moldable Synthetic Polymer, in Open Socket Preservation Without a Membrane (Original)
Krasny K., Wroblewski S., Wojtowicz A., Kaminski A.
Biomaterials · 2021
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